Based on this, anecdotal sources report a dose of 10-20mcg/kg, which would be equal to 1-2mg for a 200lb test subject
Transportation across the BBB occurs via a glucose transporter
For the scenario of "Cognitive Enhancement Research," research data suggests Dihexa may be more relevant
These effects happen systemically, not just locally
It was originally isolated in 1977 from the cerebral venous blood of rabbits and has since been found to be present in small amounts in human brains and plasma, with higher concentrations later in the day.3 4 It, or a similar substance, is also present at higher concentrations in human breast milk.5 Because DSIP can cross the blood-brain barrier and is easily absorbed via the gut (unusual for a peptide), some researchers have hypothesized that it may facilitate post-feeding sleep tendencies among newborns, though it remains unclear whether DSIP truly has a hand in neonate sleep-wake cycles.4 5 6 Its mechanism of action is likewise unclear, but it may have something to do with endocrine regulation
